Public Deliverables

3103

PATROLS MODA

Computational modelling methods provide useful tools that support the development of novel materials (including nanomaterials) (Mikolajczyk, et al. 2016; Sikorska, et al. 2016) as well as assist in their risk assessment (Gajewicz, et al. 2012). Wide opportunities offered by these techniques attracted the interest of scientific communities and industry. Benefits from the application of modelling techniques in the risk assessment of nanomaterials and directions for further development were recently highlighted in publications summarizing discussions at the level of the EU NanoSafety Cluster (Puzyn et al., 2018) as well as in the “EU-US Nanoinformatics 2030 Roadmap” worked out within the joined EU-US initiative

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2112

Critical toxicity data for IVIVE based on existing in vivo oral and inhalation toxicity studies

The in vivo anchoring of in vitro assays depends on two major presumptions; first, that the adverse pathway can be mimicked in cell assays, and second, that the ENM can reach the target tissues and interact with the relevant cell types. Existing high quality in vivo toxicity data generated for the selected ENM after repeated exposures have been collected from PATROLS partners and the scientific literature. Data for crystalline silica (DQ12) have been included for comparison and benchmarking.

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2806

Materials acquisition, physicochemical intrinsic properties and endotoxin evaluation on Tier 1 and 2 ENM

Materials with high regulatory and industrial relevance have been identified from the French inventory “R-nano”, which is based on mandatory industrial reporting of all materials produced or imported in nanoform (Ministère de l'Environnement 2015). Tier 1 PATROLS materials were selected from OECD ENM, were subsampled or newly synthesised material sub-samples were made accessible from JRC-Ispra and the Fraunhofer Institute via the PATROLS web-order system.

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3110

Extended evaluation of repeated-exposure inhalation and intra-tracheal instillation toxicity studies

Task 2.2 was not supposed to perform new inhalation studies, (unless new data are really required) and rather to collect preserved tissues and redistribute those tissues to the project partners for generation of new data. BASF was responsible for coordinating the collection and distribution of available histological sections and paraffin embedded/frozen tissues among WP2 partners.

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1211

Advanced long term exposure ecotoxicity bioassays for a variety of species across a food chain.

Increasing use of engineered nanomaterials (ENMs) in consumer goods have raised concern whether they can have detrimental effects on human and/or environmental health. Recent reviews have summarized the effects of ENMs on different organisms (e.g. Do Amaral et al. 2019; Lewis et al. 2019; Hou et al. 2018); however, it remains unclear which organisms are most sensitive and which parameters are most crucial to monitor during the tests.

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3103

Effects of subchronic oral exposure to ENM

Within WP2 of PATROLS, an overview of all internally available tissues was made. The tissues that were available for the inhalation route of exposure were listed in the Deliverable 2.2 report. Table 1 of the present report lists the available tissues from the oral exposure studies. It includes studies that used ENM application by oral gavage as well as studies in which ENM were provided ad libitum via introduction in feed pellets.

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2804

ENM dispersibility and physicochemical exposure relevant properties

In response to WP1 specific objective: “Fit for purpose characterization of physicochemical properties to support test specific exposure, fate and dosimetry assessment”, the WP1 focused the characterization on two main issues that govern the dose, once NPs come in contact with the biological environment.

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