Advancing Adverse Outcome Pathway (AOP) Development for Nanomaterial Risk Assessment

Save the dates! You are invited to two workshops: Advancing Adverse Outcome Pathway (AOP) Development for Nanomaterial Risk Assessment and PATROLS Stakeholders Workshop to be held on the 11-12 September 2019 at the OECD Conference Centre, Paris

Sept 11: OECD Workshop jointly organized with EU H2020 projects SmartNanoTox and PATROLS

This workshop will bring together AOP and manufactured nanomaterials (MN[NG-N1] ) research, regulation and policy experts to discuss the use of Adverse Outcome Pathway (AOP) frameworks to support future NM risk assessment. It will include presentations and discussions on three related projects:

  • The OECD WPMN NanoAOP project aiming to develop an approach to advance the future development of AOPs for NMs using existing nanotoxicology literature;
  • The EU H2020 SmartNanoTox project, using in vivo, in vitro and in silico research to develop MN-relevant AOPs in the respiratory pathway; and
  • The EU H2020 PATROLS project, developing non-animal (in vitro) models and computational tools targeting the key events in established AOPs.

The workshop will include presentations and break-out discussions to disseminate and gain expert input on the results of these projects. Experts will comment on how outcomes from these three related projects can be used advance future AOP development to support decision making (e.g. grouping, categorization, read-across, and/or quantitative dose response relationships) and to derive regulatory oversight.

Sept 12: PATROLS Project Stakeholder Workshop

PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) is holding a stakeholder workshop to present and discuss advanced methods and tools being developed within the project, which can also be used to support development of AOPs for nanomaterial hazard assessment.

The workshop will include presentations on advanced systems in the areas of: Ecotoxicology; In silico hazard testing systems; In vitro human tissue models; and characterisation in biological systems.

The aim of the workshop is to showcase and seek stakeholder feedback on tools being developed within PATROLS, and participants are encouraged to take an active role in our discussions.

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